Aging, as a process, still remains a mystery to modern science. We know that it’s not just one thing that causes the symptoms of aging which is what makes it so hard to find a miracle compound that erases everything. Still we’ve made some pretty good progress in combating some parts of the aging process, many of which can be used to make our lives not only longer but also far more healthier throughout. The latest research from scientists at the Mayo clinic shows yet another potential pathway for delaying the onset of age related diseases and conditions, giving mice up to 35% longer lives.
The mechanism that the researchers focused on is called cellular senescence. Our cells constantly reproduce themselves through division, a process which repeats for each cell approximately 40 to 60 times before it enters a stage called cellular senescence. In this stage the cell’s telomeres, a kind of nucleotide that protects a cell’s DNA from damage, is shortened to the point where it can no longer provide the protection the cell needs. In this stage the cell will no longer divide but still remains active. Eventually these senescent cells are cleaned out by the body’s immune system but as we age this process starts to slow down and become less efficient.
The Mayo researchers used an existing transgene line, called INK-ATTAC, to induce cell death in these senescent cells. This was triggered by twice weekly injections into two different lines of lab mice who were then compared to a control. The results were incredibly impressive, showing an improvement in overall lifespan of the mice from 17% to 35%. The mice also showed no side effects from the treatment with healthy major organ function retained throughout their extended life. Suffice to say a treatment of this nature would appear to be of incredible benefit to many, especially those who are seeking more healthy years than just an extended lifespan.
Such a treatment is probably many years away from reaching humans however, mostly due to the fact that the use of transgenes in humans is still an open area of bioethical debate. Indeed whilst the consensus for using such treatments for curative purposes appears to be largely agreed upon therapeutic uses such as these are still something of a grey area. Transgenes like this one are still very much an area of active research however and there are likely to be many more such treatments like these developed in the coming years. Hopefully the regulatory and ethical frameworks will be able to keep up with the rapid pace of innovation as treatments like these are invaluable in treating the one condition that affects all humans universally.